Nanostructured lipid carrier nlc was prepared by homogenization emulsification. Development of simvastatin loaded nanostructured lipid. These lipid nanoparticles are known as solid lipid nanoparticles slns and nanostructured lipid carriers, which are attracting wide attention of formulators worldwide. Nanotechnology having developed exponentially, the aim has been on therapeutic undertaking, particularly for cancerous disease chemotherapy. The synergy between nanostructured lipid carriers nlc and chemical penetration enhancers provides the basis for a promising strategy to effectively deliver drugs through the skin. This study aimed to improve the drug solubility and prolong drug release by developing nanostructured lipid carriers nlcs for dac delivery.
This thesis is dedicated to my parents, who have given me invaluable. Design and evaluation of miconazole nitrate loaded nanostructured lipid carriers nlc for improving the antifungal therapy gajanan s sanap1, guru prasad mohanta2 1department of pharmacy, karpagam university, coimbatore641 021 tamil nadu, india. After a process of preparation, remove solvents in sample by rotary vacuum evaporator at. Hot high pressure homogenization with the capability for scale up production was successfully used to manufacture the nanocarriers without the use of toxic organic solvents for the first time. Preparation and characterization of minoxidil loaded. Schematic view of the solid lipid nanoparticle sln and nanostructured lipid carriers nlcs showing the drug location. Masters thesis, college of pharmacy, madurai medical college, madurai, tamil nadu, india. Particle size and physical state of the lipid phase are major factors influencing the permanence of lipid dispersions.
Development and characterization of lipid nanoparticles. Tujuan kajian ini adalah untuk menyediakan pembawa lipid nanostruktur nlc lopinavir tidak larutair dan verapamil larut air. Formulation and characterization of nanostructured lipid. Oct 10, 2019 the larval stage of the tapeworm echinococcus granulosus is the causative agent of hydatid disease in humans. Lipidbased nanosystems have great potential for transdermal drug delivery. Nanostructured lipid carrier nlc was prepared by homogenization emulsification method and improved with modified surfactants. Nanostructured lipid carriers as a drug carrier open access. Pdf design of nanostructured lipid carriers ubiquinone10 for. Sln and nlc are advantageous colloidal drug carrier systems over their colloidal counterparts such as polymeric nanoparticles, liposomes and microemulsions 4. Preparation and characterization of vinpocetine loaded. It also overcomes the disadvantages of various lipid particulate carriers due to the various advantages of. Nanostructured lipid carriers nlc are a delivery system in which partialcrystallized lipid particles with mean radii. Natural lipids in nanostructured lipid carriers and its.
Sln are produced using solid lipids including highmelting point glycerides or waxes, replacing liquid lipid. A third generation of lipid matrix was designed as nanostructured lipid carrier nlc is a blend of mixture of solid lipids along with spatially incompatible liquid lipids. Although cold homogenization minimizes the thermal exposure of the sample, but it cannot be completely avoidable as melting of the lipiddrug mixture is required. Formulation and evaluation of nanostructured lipid. The influences of liquid medium chain triglycerides mct and solid glyceryl tristearate gts contents in the lipid matrix of nanostructured lipid carriers nlcs on their delivering capacities for cur were investigated herein by simulated gastrointestinal tract and caco2 monolayer models. Nanostructured lipid carriers nlcs for drug delivery and. This thesis explores drug delivery systems based on solid lipids. Many compounds with high lipophilic character incorporated into nanostructured lipid carriers nlc have been reported. Produced from blends of solid lipids and liquid lipids. Published under licence by iop publishing ltd journal of physics.
In this paper, we investigated the potential of lipid nanoparticles as carriers for aqueous extract of spirogyra spp. Solid lipid nanoparticles and nanostructured lipid carriers. Formulation and characterization of hydroquinone nanostructured. Professor luis joaquim pina da fonseca professor jorge humberto gomes leitao. Solid lipids are mixed with liquid lipids preferably in the ratio of 70. Nlcs were prepared by melt and ultrasonication method, characterised by cryotem for morphology and sdfff for dimensional. Nanostructured lipid carriers nlc for the delivery of natural molecules with antimicrobial activity. Nanostructured lipid carriers nlcs consist of a solid lipid matrix with a certain amount of liquid lipid, and were introduced as a novel delivery system for various cosmetic active ingredients and pharmaceutical drugs. Gastrointestinal mucoadhesion, absorption and biodistribution. In the present work, focus is given to the study of the interaction of limonene, ethanol, and carbopol ultrez 10nf, as the gelling agent, with a coencapsulating nlc dispersion, containing both olanzapine and. Nov 20, 2012 nanotechnology having developed exponentially, the aim has been on therapeutic undertaking, particularly for cancerous disease chemotherapy. Preparation and characteristics of nanostructured lipid carrier nlc loaded red ginger extract using high pressure homogenizer method siti sadiah1,2,3, effionora anwar 1, mahdi djufri, umi cahyaningsih2 1faculty of pharmacy, university of indonesia, indonesia 2faculty of veterinary medicine, bogor agricultural university, indonesia 3tropical biopharmaca research center, bogor agricultural. Solid lipid nanoparticles and nanostructured lipid carriers as novel. Lipid nanoparticles have shown promising results and progress are being made in this novel drug delivery system 17,18.
Lipid nanoparticles are colloidal carriers which have shown a high potential as a suitable drug carrier because of their. A novel generation of solid lipid drug carriers magdalene radtke is a research scientist at pharmasol gmbh, germany. Nanostructured lipid carriers nlcs are drugdelivery systems and they are made out of solid and fluid lipids as a core matrix. Mller rh, petersen rd, hommoss a, pardeike j 2007 nanostructured fat carriers nlc in cosmetic dermal products. Preparation and characterisation of nobiletinloaded. In view of the ineffectiveness of some drug treatments, the surgical removal of cysts remains the preferred treatment option together with the administration of. Additionally, this study was focused on the application of nobloaded nlc nobnlc in functional food.
Development of nanostructured lipid carrier for dacarbazine. Among the formulations above, the nanostructure lipid carriers nlcs are regarded as the secondgeneration of lipid nanoparticlesthe purpose of this study is to develop an optimized nanostructured lipid carriers nlc formulation for ritonavir, and to estimate the potential of nlc as oral delivery system for poorly watersoluble drugs. These biocompatible andor biodegradable lipids based nanoparticles are composed of solid and liquid lipids as a core matrix dispersed in surfactant solution. Aug 30, 2012 among the formulations above, the nanostructure lipid carriers nlcs are regarded as the secondgeneration of lipid nanoparticlesthe purpose of this study is to develop an optimized nanostructured lipid carriers nlc formulation for ritonavir, and to estimate the potential of nlc as oral delivery system for poorly watersoluble drugs. Nanostructured lipid carrier system for the treatment for. Nanostructured lipid carriers have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceutical consignment, particularly anticancer pharmaceuticals. It was demonstrated that nlcs uncover a few points of interest for medication treatment conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, prolonged halflife, reduced. Lipid nanoparticles are a promising alternative to traditional colloidal drug carriers.
Design of a nanostructured lipid carrier intended to. Quercetin loaded nanostructured lipid carriers based gel for rheumatoid arthritis 3969 qct, solid lipid gms and qctnlcs. Pdf preparation and characterization of nanostructured lipid. Phd thesis iron oxide nanoparticles and their toxicological. Nanostructured lipid carriers are a new type of delivery system offering improved performance in terms of drug loading and longterm stability with the ability to form highly concentrated dispersions. Sudhakar, s 2014 development of simvastatin loaded nanostructured lipid carriers based hydrogels for diabetic wound healing.
The properties of nanoparticles were investigated using the nlc system for hydroquinone hq as a model drug and by increasing the light stability of hydroquinone. Slns and nanostructured lipid carriers nlcs are promising delivery systems due to the ease of. Quercetin loaded nanostructured lipid carriersbased gel. The main reason for this is related with the wellknown conception that lipids promote oral drug absorption, because they undergo the same physiological mechanisms of food lipid digestion.
Full text design of a nanostructured lipid carrier intended. Pdf in this study, we aimed to investigate the influence of liquid lipid types on different. Nanostructured lipid carriers, curcumin, drug release, cytotoxicity, liquid lipid. Nanostructured lipid carriers nlcbased topical gel of etoricoxib was prepared with the aim. Nanostructured lipid carriers nlcs are drugdelivery systems composed of both solid and liquid lipids as a core matrix. Nanostructured lipid carriers of ivermectin as a novel. Sln are produced using solid lipids including highmelting point glycerides.
Herein, we hypothesize that nanostructured lipid carriers nlcs could activate the endogenous glucagonlike peptide1 glp1 secretion and also act as oral delivery systems for glp1 analogs exenatide and liraglutide. Preparation and characterization of vinpocetine loaded nanostructured lipid carriers nlc for improved oral bioavailability july 2010 international journal of pharmaceutics 39412. Response surface method with a threelevel boxbehnken design was. We looked for np answers to the following questions. The optimized condition of nlc in stirring was 1200 rpm, the homogenized speed was 8000 rpm, solid oil. Nlc disediakan dengan menggunakan lipid pepejal compritol 888 ato, lipid cecair asid oleik, dan surfaktan poloxamer 188 dan tween 80 the aim of the present study was to prepare nanostructured lipid carriers nlcs of lopinavir water insoluble and verapamil. Valloaded nlcs were prepared using ultrasonic meltemulsification method. Carvacrol loaded nanostructured lipid carriers as a. It is foreseen that, in the beside future, nanostructured lipid carriers will be further advanced to consign cytotoxic anticancer compounds in a more. Topical drug application has been introduced since long time to. The aim of the present study was to encapsulate rutin by nanostructured lipid carriers rnlcs, as a. Natural lipids in nanostructured lipid carriers and its cytotoxicity.
Oleic acidloaded nanostructured lipid carrier inhibits neutrophil activities in the presence of albumin and alleviates skin inflammation chunyu chen,1,2 yinghsuan lee,1 shihhsin chang,1,35 yungfong tsai,1,2 jiayou fang,5 tsonglong hwang,5,61graduate institute of natural products, college of medicine, chang gung university, taoyuan 333, taiwan. Design and evaluation of miconazole nitrate loaded. The short term stability of efavirenzloaded solid lipid nanoparticle and nanostructured lipid carrier dispersions was investigated. Encapsulation of ascorbyl palmitate in nanostructured lipid carriers nlc. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems. Because the skin serves as a protective barrier against the outside world, any. This paper intends to describe briefly the different lipid based. Solid lipid nanoparticles sln and nanostructured lipid carriers nlc structural investigations on two different carrier systems. To optimize a nanostructured lipid carriers system nlc for the peroral delivery of valsartan val, a model bcs class ii drug, in an attempt to enhance its therapeutic performance by increasing both solubility and dissolution. This zoonotic parasitic infection remains a major health problem in certain areas of the world where is still endemic.
Pharm thesis submission, dayanand dinanath college, institute of pharmacy, dr. Slns and nlcs are colloidal carriers developed in the last decade as an alternative system to the existing traditional carriers emulsion, liposomes and polymeric nanoparticles. Skin cancer, nanostructured lipid carriers, topical drug delivery, drug targeting. Pdf solid lipid nanoparticles and nanostructured lipid. Sep 21, 2015 dacarbazine dac is one of the most commonly used chemotherapy drugs for treating various cancers. Influence of oil composition on the transformation. Nano structured lipid carriers nlc, topical drug delivery system, solid. Formulation and evaluation of nanostructured lipid carriers. Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis marina pinheiro,1, ricardo ribeiro,1, alexandre vieira,1, fernanda andrade,2 salette reis1 11ucibio, requimte, chemistry department, faculty of pharmacy, 2laboratory of pharmaceutical technology, department of drug sciences, faculty of pharmacy, university of porto, porto, portugal these authors. The stimulation of glp1 secretion and delivery of glp1.
However, its poor water solubility, short halflife in blood circulation, low response rate and high side effect limit its application. Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment. Nanostructured lipid carriers nlc are one of the promising nanocarriers for the development of effective targeted therapies for cancer chemotherapeutics. The purpose of this study was to develop an optimised formulation for a nanostructured lipid carrier nlc loaded with. Oleic acidloaded nanostructured lipid carrier inhibits.
However, hydrophilic compounds have not been completely investigated. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. It was shown that nlcs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged halflife, and tissuetargeted. Solid lipid nanoparticles and nanostructured lipid. Preparation and characterization of nanostructured lipid. Nanostructured lipid carriers as a delivery system of tobramycin and ciprofloxacin. Nanostructure lipid carrier rahul dalvi linkedin slideshare. Nov 20, 2012 solid lipid nanoparticles sln and nanostructured lipid carriers nlc in cosmetic and dermatological preparations. Nanostructured lipid carriers nlc are one of the promising nano carriers for the development of effective targeted therapies for cancer chemotherapeutics.
The purpose of this research was to formulate lipid nanoparticles lipid emulsions le, nanostructured lipid carriers nlc and polymer coatednlc for delivery of anticancer drug, alltrans retinoic acid atra. The samples, weighing 2 mg, were analyzed in sealed and pinholed standard 40 l aluminum pans, with a heating rate of 10 ocmin from 30c to 400oc and during the. Nlcs effectively encapsulated the peptides, the majority of which were only released under the intestinal conditions. These carrier systems overcome observed limitations of conventional sln. It was shown that nlcs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged halflife, and tissue. Potential problems associated with sln namely, limited drug loading, risk of gelation and drug leakage during storage caused by lipid polymorphism have been further minimized by a new generation of lipid systems, the nanostructured lipid carriers nlc developed at the turn of the millennium muller et al. The objective of this manuscript was to investigate and optimise the potential of nanostructured lipid carriers nlcs as a carrier system for nobiletin nob, which was prepared by highpressure homogenisation method. Nanostructured lipid carriers as a drug carrier open. Dacarbazine dac is one of the most commonly used chemotherapy drugs for treating various cancers. Tan, janet sui ling 2020 gastrointestinal mucoadhesion, absorption and biodistribution of orally administered chitosancoated amphotericin b nanostructured lipid carriers nlc formulation.
This study describes the preparation, characterisation and in vitro activity of nanostructured lipid carriers nlcs encapsulating natural molecules with antimicrobial activity, such as plumbagin, hydroquinon, eugenol, alphaasarone and alphatocopherol. Classification of nlc based on the nanostructure, composition and ratios of solid and liquid lipids. Englishthis thesis deals with the studies carried out by the writer for the past four years. Preparation and characteristics of nanostructured lipid. Open access full text article effect of compositions in. Nanostructured lipid carriers nlc for the delivery of. The larval stage of the tapeworm echinococcus granulosus is the causative agent of hydatid disease in humans.
Nlcs, containing mixed lipids solid fat and liquid oil, have many advantages over solid lipid nanoparticles slns. Appendages such as hairs and glands are derived from, and linked to, the epidermis but project deep into the dermal layer. The blends obtained are also solid at room temperature and body temperature. As one of the main types of lipid nanoparticles, nanostructured lipid carriers nlcs act as an alternative carrier system to emulsions, liposomes and polymetric nanoparticles. Nanostructured lipid carriers of ivermectin as a novel drug.
483 1471 597 755 463 1630 1189 1484 1330 241 1374 316 934 534 1307 362 815 757 860 210 426 1059 145 1595 1255 844 1231 853 101 277 1040 507 377 906 1077 535 1273 1129 1448 973 1327